A Trial to Assess How Centanafadine Interacts With Stimulants in the Body
Phase 1
42
about 31 days
18–55
1 site in UT
What this study is about
Researchers are testing how centanafadine interacts with stimulants when taken together. The trial will examine if combining these medications affects the body's response.
Simplified from trial records by PatientMatch.
What you may be asked to do
- 1.Take Centanafadine
- 2.Take Lisdexamfetamine
- 3.Take Methylphenidate
Participation Burden
What's physically and logistically required of participants.
Requires travel to a study site
How treatment is administered
You may get a placebo/standard care, and you won't know which.
Extracted study details
Pulled from the trial record to show what is being tested and what the study is measuring.
lisdexamfetamine, methylphenidate (CNS stimulant; blocks reuptake of dopamine and norepinephrine)
oral (Disintegrating Oral Tablet)
Primary: Change from Baseline in Blood Pressure (BP) at Day 12 or Early Termination (ET), Change from Baseline in Heart Rate (HR) at Day 12 or ET
Secondary: Apparent clearance of drug from plasma after extravascular administration (CL/F) for Centanafadine when co-administered with methylphenidate or lisdexamfetamine, Area under the concentration time curve from time zero to infinity (AUC-inf) for Centanafadine when co-administered with methylphenidate or lisdexamfetamine, Maximal peak plasma concentration (Cmax) for Centanafadine when co-administered with methylphenidate or lisdexamfetamine, Terminal phase elimination half-life (t1/2,z) for Centanafadine when co-administered with methylphenidate or lisdexamfetamine, Time to maximum (peak) Plasma Concentration (Tmax) for Centanafadine when co-administered with methylphenidate or lisdexamfetamine
Psychiatry / Mental Health