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A Study to Assess Adverse Events and Change in Disease Activity Comparing Oral Upadacitinib to Subcutaneous Dupilumab in Children From 2 to Less Than 12 Years of Age With Moderate to Severe Atopic Dermatitis

AbbVie
NCT IDNCT06461897ClinicalTrials.gov data as of Apr 2026
Phase

Phase 3

Target enrollment

675

Study length

about 6 years

Ages

2–11

Locations

30 sites in AR, CA, FL +16

What this study is about

This trial is testing whether oral upadacitinib or subcutaneous dupilumab is better at controlling moderate to severe atopic dermatitis in children aged 2 to under 12. Participants will receive either upadacitinib (taken daily) or dupilumab (given every 2 or 4 weeks), and it will last for about 2 years, with regular visits to monitor their condition and check for side effects.

Simplified from trial records by PatientMatch.

What you may be asked to do

  • 1.Take Dupilumab
  • 2.Take Upadacitinib

Participation Burden

What's physically and logistically required of participants.

Logistics & Travel
In-person visits

Requires travel to a study site

Physical Intervention
Oral

How treatment is administered

Treatment Assignment
Randomized & Blinded

You may get a placebo/standard care, and you won't know which.

Extracted study details

Pulled from the trial record to show what is being tested and what the study is measuring.

Drug classes

dupilumab, upadacitinib

Drug routes

oral (Oral Solution)

Endpoints

Primary: Number of Participants with Adverse Events (AEs)

Body systems

Dermatology