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Study details
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Axatilimab Trial

OHSU Knight Cancer Institute
NCT IDNCT06320405ClinicalTrials.gov data as of Apr 2026
Phase

Phase 1/2

Target enrollment

38

Study length

about 4.9 years

Ages

18+

Locations

1 site in OR

What this study is about

This trial is testing the safety, side effects, and effectiveness of axatilimab when combined with retifanlimab and paclitaxel for people with advanced or metastatic solid tumors. Axatilimab is a monoclonal antibody that may interfere with tumor growth and spread. Retifanlimab helps the immune system attack cancer cells, and paclitaxel stops cancer cell growth and division. This combination treatment aims to be safe, tolerable, and potentially effective in treating these cancers.

Simplified from trial records by PatientMatch.

What you may be asked to do

  • 1.Receive Axatilimab
  • 2.Receive Retifanlimab
  • 3.Take Paclitaxel
  • +3 more

Participation Burden

What's physically and logistically required of participants.

Logistics & Travel
In-person visits

Requires travel to a study site

Physical Intervention
Injection / IVInjection / IV

How treatment is administered

Treatment Assignment
All receive treatment

Everyone gets the investigational treatment.

Extracted study details

Pulled from the trial record to show what is being tested and what the study is measuring.

Drug classes

Anti-inflammatory Agent (Colony Stimulating Factor Receptor Type 1 (CSF-1R) Inhibitors), paclitaxel (Taxane chemotherapy; stabilizes microtubules), retifanlimab

Drug routes

injection, intravenous

Procedures

biopsy, diagnostic, imaging

Body systems

Oncology