Preventing Injured Knees From Osteoarthritis: Severity Outcomes
Phase 2
512
about 5.7 years
18–45
9 sites in GA, IA, KY +5
What this study is about
This trial is testing if metformin can help prevent post-traumatic osteoarthritis (PTOA) after an ACL tear. It compares metformin to a placebo, which looks like metformin but has no active ingredient. Metformin is used to treat type II diabetes and also has anti-inflammatory properties.
Simplified from trial records by PatientMatch.
What you may be asked to do
- 1.Take Metformin
- 2.Take Placebo
Participation Burden
What's physically and logistically required of participants.
Requires travel to a study site
How treatment is administered
You may get a placebo/standard care, and you won't know which.
Extracted study details
Pulled from the trial record to show what is being tested and what the study is measuring.
metformin (Biguanide antidiabetic; reduces liver glucose production and improves insulin sensitivity)
oral
Primary: KOOS Pain Score
Secondary: KOOS Activities of Daily Living (ADL), KOOS Pain, KOOS Quality of Life, KOOS Symptoms, Knee Range of Motion, Severity of Synovitis on Contrast MRI
Musculoskeletal