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Study details
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Emergency Department Medications for Alcohol Use Disorder

Yale University
NCT IDNCT05827159ClinicalTrials.gov data as of Apr 2026
Phase

Phase 3

Target enrollment

240

Study length

about 3.5 years

Ages

18–80

Locations

1 site in CT

What this study is about

This trial is testing a new way to treat moderate to severe alcohol use disorder (AUD) in the emergency department. It combines brief counseling with medications like naltrexone or gabapentin, given as an injection or pill. The goal is to see if this approach helps people stay engaged in treatment and reduce heavy drinking days after their visit to the ED.

Simplified from trial records by PatientMatch.

What you may be asked to do

  • 1.Participate in Brief Negotiation Interview
  • 2.Receive Naltrexone Injection
  • 3.Take Gabapentin Pill
  • +1 more

Participation Burden

What's physically and logistically required of participants.

Logistics & Travel
In-person visits

Requires travel to a study site

Physical Intervention
OralInjection / IV

How treatment is administered

Treatment Assignment
Randomized (Open Label)

You are randomly assigned, but you will know your treatment.

Extracted study details

Pulled from the trial record to show what is being tested and what the study is measuring.

Drug classes

anticonvulsant (Modulates calcium channels; used for neuropathic pain and seizures), naltrexone, NERVOUS SYSTEM

Drug routes

oral (Oral Tablet), injection, intramuscular, injection (Injection), oral

Endpoints

Secondary: Alcohol withdrawal symptoms

Body systems

Psychiatry / Mental Health