DOMINICA Trial
Phase 3
200
about 9.1 years
6–18
28 sites in AL, AR, AZ +16
What this study is about
This trial is testing benralizumab, a drug given by injection, in children with severe asthma. The goal is to see if benralizumab helps reduce the frequency of asthma attacks compared to a placebo.
Simplified from trial records by PatientMatch.
What you may be asked to do
- 1.Take Benralizumab
- 2.Take Placebo
Participation Burden
What's physically and logistically required of participants.
Requires travel to a study site
How treatment is administered
You may get a placebo/standard care, and you won't know which.
Extracted study details
Pulled from the trial record to show what is being tested and what the study is measuring.
benralizumab
Secondary: Change from baseline, during the DB treatment period in Asthma symptom score, Change from baseline, during the DB treatment period in Interviewer-Administered Version of the Asthma Control Questionnaire (ACQ-IA), Change from baseline, during the DB treatment period in Paediatric Asthma Quality of Life Questionnaire-Interviewer Administered (PAQLQ-IA) total score, Change from baseline, during the DB treatment period in night-time awakenings due to asthma, Change from baseline, during the DB treatment period in peak expiratory flow (PEF), Change from baseline, during the DB treatment period in rescue medication use, Change from baseline, during the DB treatment period, in spirometry, for post-bronchodilator FEV1, Change from baseline, during the DB treatment period, in spirometry, for pre-dose/pre-bronchodilator forced expiratory volume in one second (FEV1)
Respiratory