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Study details
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ComboMATCH Screening Trial

National Cancer Institute (NCI)
NCT IDNCT05564377ClinicalTrials.gov data as of Apr 2026
Phase

Phase 2

Target enrollment

2,900

Study length

about 7.2 years

Ages

All ages

Locations

476 sites in AK, AL, AR +41

What this study is about

This trial is testing a new way to treat cancer by matching it to the patient's unique genetic makeup. The goal of this screening trial is to identify patients who might benefit from targeted therapies based on their tumor's specific genetic mutations. It aims to find treatments that could control tumors and help doctors plan better treatment for people with locally advanced or advanced solid tumors.

Simplified from trial records by PatientMatch.

What you may be asked to do

  • 1.Receive Panitumumab
  • 2.Take Alpelisib
  • 3.Take Binimetinib
  • +3 more

Participation Burden

What's physically and logistically required of participants.

Logistics & Travel
In-person visits

Requires travel to a study site

Physical Intervention
OralOral

How treatment is administered

Treatment Assignment
All receive treatment

Everyone gets the investigational treatment.

Extracted study details

Pulled from the trial record to show what is being tested and what the study is measuring.

Drug classes

alpelisib, binimetinib, fluorouracil (Antimetabolite; mimics uracil to disrupt DNA/RNA in cancer cells), fulvestrant, Antidotes, Deterrents, and Toxicologic Agents (Enzyme Interactions), Antineoplastic Agent [TC] (Kinase Inhibitors), Antineoplastic Agent [TC] (Bcr-Abl Tyrosine Kinase Inhibitors), olaparib

Drug routes

oral (Oral Tablet), oral (Oral Capsule), injection, injection (Injection), oral, intravenous

Procedures

biopsy, diagnostic, imaging

Body systems

Oncology