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Study details
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Endometriosis and Microvascular Dysfunction; Simvastatin and Duavee

Penn State University
NCT IDNCT05059626ClinicalTrials.gov data as of Apr 2026
Phase

Phase 4

Target enrollment

28

Study length

about 3.1 years

Ages

18–45

Sex

Female only

Locations

1 site in CT

What this study is about

This trial is testing whether a treatment with Bazedoxifene, conjugated estrogen, simvastatin, and Duavee improves microvascular function in women with endometriosis. The goal is to see if these interventions reduce inflammation and improve blood vessel health.

Simplified from trial records by PatientMatch.

What you may be asked to do

  • 1.Take Bazedoxifene 20/Estrogens,Con 0.45Mg Tb
  • 2.Take simvastatin 10mg

Participation Burden

What's physically and logistically required of participants.

Logistics & Travel
In-person visits

Requires travel to a study site

Physical Intervention
Oral

How treatment is administered

Treatment Assignment
Randomized & Blinded

You may get a placebo/standard care, and you won't know which.

Extracted study details

Pulled from the trial record to show what is being tested and what the study is measuring.

Drug classes

bazedoxifene, Hormonal Agents, Stimulant/Replacement/Modifying (Sex Hormones/Modifiers) (Estrogen Receptor Agonists), simvastatin (Statin; lowers cholesterol via HMG-CoA reductase inhibition)

Drug routes

oral

Body systems

Reproductive Health