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Study details
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Stimulant vs. Non-stimulant Treatments and Reward Processing in Drug-naive Youth at SUD Risk

Icahn School of Medicine at Mount Sinai
NCT IDNCT03781765ClinicalTrials.gov data as of Apr 2026
Phase

Phase 4

Target enrollment

44

Study length

about 6.3 years

Ages

7–12

Locations

1 site in NY

What this study is about

This trial is testing whether stimulant or non-stimulant medications for ADHD affect brain reward systems in children who are not currently taking medication. Researchers will use fMRI to see how these treatments impact the brain's response to rewards.

Simplified from trial records by PatientMatch.

What you may be asked to do

  • 1.Take Atomoxetine
  • 2.Take Methylphenidate

Participation Burden

What's physically and logistically required of participants.

Logistics & Travel
In-person visits

Requires travel to a study site

Physical Intervention
OralOral

How treatment is administered

Treatment Assignment
All receive treatment

Everyone gets the investigational treatment.

Extracted study details

Pulled from the trial record to show what is being tested and what the study is measuring.

Drug classes

atomoxetine, methylphenidate (CNS stimulant; blocks reuptake of dopamine and norepinephrine)

Drug routes

oral (Oral Capsule), oral (Disintegrating Oral Tablet)

Body systems

Psychiatry / Mental Health