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Study details
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T Cell Receptor Immunotherapy for Patients With Metastatic Non-Small Cell Lung Cancer

National Cancer Institute (NCI)
NCT IDNCT02133196ClinicalTrials.gov data as of Apr 2026
Phase

Phase 2

Target enrollment

85

Study length

about 13 years

Ages

18–72

Locations

1 site in MD

What this study is about

This trial is testing a new treatment called T cell receptor immunotherapy to see if it can shrink tumors in people with advanced non-small cell lung cancer. It involves taking special immune cells from the patient's tumor, growing them in a lab, and then giving them back to the patient. This treatment may be given along with chemotherapy.

Simplified from trial records by PatientMatch.

What you may be asked to do

  • 1.Receive Young TIL
  • 2.Take Aldesleukin
  • 3.Take Cyclophosphamide
  • +1 more

Participation Burden

What's physically and logistically required of participants.

Logistics & Travel
In-person visits

Requires travel to a study site

Physical Intervention
Injection / IV

How treatment is administered

Treatment Assignment
All receive treatment

Everyone gets the investigational treatment.

Extracted study details

Pulled from the trial record to show what is being tested and what the study is measuring.

Drug classes

aldesleukin, cyclophosphamide (Alkylating chemotherapy; crosslinks DNA strands), fludarabine

Drug routes

infusion

Endpoints

Primary: Response rate

Secondary: Frequency and severity of treatment-related adverse events

Body systems

Oncology