Study details
Enrolling now
Pyrimethamine, Sulfadiazine, and Leucovorin for Congenital Toxoplasmosis
National Institute of Allergy and Infectious Diseases (NIAID)
NCT IDNCT00004317ClinicalTrials.gov data as of Apr 2026
Phase
Phase 4
Target enrollment
600
Study length
about 30 years
Ages
All ages
Locations
1 site in IL
What this study is about
This trial is testing whether a specific combination of medications (pyrimethamine, sulfadiazine, and leucovorin) is more effective than another regimen when treating infants with congenital toxoplasmosis. The goal is to determine the best way to use pyrimethamine in this situation.
Simplified from trial records by PatientMatch.
What you may be asked to do
- 1.Take Leucovorin calcium
- 2.Take Pyrimethamine
- 3.Take Spiramycin
- +1 more
Participation Burden
What's physically and logistically required of participants.
Logistics & Travel
In-person visits
Requires travel to a study site
Physical Intervention
OralOral
How treatment is administered
Treatment Assignment
Randomized & Blinded
You may get a placebo/standard care, and you won't know which.
Extracted study details
Pulled from the trial record to show what is being tested and what the study is measuring.
Drug classes
calcium folinate, pyrimethamine, spiramycin, sulfadiazine
Drug routes
oral (Oral Tablet)